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Treatments Targets & Results

 

 

World overview

UNAIDS/WHO estimates that nearly 40 million people were living with HIV at the end of 2004. A person who is HIV positive is likely to ultimately become sick with an AIDS-related condition, but if treated with antiretroviral (ARV) medication, their life can be prolonged, often for many years.

At the end of June 2005, UNAIDS/WHO estimated that 6.5 million people in developing and transitional countries urgently needed this life-saving ARV medication. Of these only 970,000 - 15% - were accessing ARV drugs. In sub-Saharan Africa, only 11% of those who needed treatment were receiving it. These numbers - still shockingly small - are a great improvement on figures from two years earlier. At the UN General Assembly Meeting on HIV/AIDS on September 22nd 2003, the WHO, UNAIDS and the Global Fund declared the lack of access to HIV treatment a global health emergency.

The percentages of HIV+ people accessing ARV treatment in richer countries make much better reading. In high-income areas, such as Western Europe, treatment is available to almost everybody who needs it. However, even in the USA, the richest country in the world, some of the poorest people who do not have health insurance are missing out on treatment. The cost of the drugs in high-income countries is now much higher than the prices being offered to developing countries, and there have been concerns that public healthcare services will not be able to shoulder the burden of paying for new expensive drugs.

There are some notable exceptions in the developing world, where people are receiving sustainable and free/cheap treatment. Brazil has been providing its citizens with ARV drugs for many years, and African countries such as Uganda and Botswana are in the process of expanding ambitious ARV distribution programmes. Other countries have made commitments to start providing free treatment, such as India. As well as countrywide initiatives, global organisations and funding bodies are rolling-out plans to increase ARV coverage.

Never before in the history of the epidemic has so much money been available to finance treatment and care for HIV+ people, and never before have antiretroviral medicines been made so cheaply and plentifully available. But still, every day, 8,000 people are dying from a disease which can be treated, but which all too often isn't.

Who sets the targets?

In December 2003, the World Health Organisation (WHO) announced a strategy aiming to bring ARV treatment to 3 million people living with HIV in developing and transitional countries by 2005. Calling this strategy the "3 by 5" initiative (3 million people by 2005), the WHO said it hoped to see 700,000 people on ARV therapy by December 2004, 1.6 million people by June 2005 and 3 million by December 2005. This 3 million represented 50% of the number of people expected to be in need of treatment at the end of 2005.

The WHO is not actually purchasing and supplying the ARVs themselves. They are working in partnership with global organisations such as UNAIDS; The Global Fund to Fight AIDS, Tuberculosis and Malaria; the US Presidential Emergency Plan for AIDS Relief; and The World Bank, as well as national governments and Non-Governmental Organisations (NGOs) already working in developing countries, to implement the new guidelines and targets, and to provide support and expertise.

Essentially, whilst they won't actually be buying drugs, they will help governments in badly-affected countries to set up a comprehensive national response to HIV and AIDS. As regards treatment, they will advise on issues such as:


The WHO 3 by 5 logo

• How to go about applying for funding to buy drugs

• How to actually purchase a regular supply of high-quality, affordable medicines

• How to train medical staff

• How to get drugs to the people who need them.

What are the targets?

By June 2004 there should be

• 20 countries using the AIDS Medicines and Diagnostics Service (AMDS) service

• 25 countries with national implementation plans

• 35 countries establishing ARV therapy targets

• 200 additional WHO staff deployed to country offices

• 1,500 partnerships between ARV therapy outlets and community-groups

• 10,000 health providers trained to provide ARV therapy

• 500,000 people receiving ARVs in developing countries.

By December 2004 there should be

• 30 countries using the AMDS service

• 35 countries with national implementation plans

• 50 countries establishing ARV therapy targets

• 400 additional WHO staff deployed to country offices

• 3,000 partnerships between ARV therapy outlets and community-groups

• 30,000 health providers trained to provide ARV therapy

• 700,000 people receiving ARVs in developing countries.

By June 2005 there should be

• 40 countries using the AMDS service

• 60 countries with national implementation plans

• 60 countries establishing ARV therapy targets

• 440 additional WHO staff deployed to country offices

• 9,000 partnerships between ARV therapy outlets and community-groups

• 70,000 health providers trained to provide ARV therapy

• 1,600,000 people receiving ARVs in developing countries.

By December 2005 there should be

• 50 countries using the AMDS service

• 60 countries with national implementation plans

• 60 countries establishing ARV therapy targets

• 480 additional WHO staff deployed to country offices

• 30,000 partnerships between ARV therapy outlets and community-groups

• 100,000 health providers trained to provide ARV therapy

• 3,000,000 people receiving ARVs in developing countries.

What progress has been made?

Estimated progress made towards treatment targets:

• 440,000 receiving treatment in June 2004

• 700,000 receiving treatment in December 2004

• 970,000 receiving treatment in June 2005.

Progress made towards other targets:

• 40 countries using the AMDS service (mid-2004)

• 40 countries with national implementation plans (December 2004)

• More than 40 countries establishing ARV therapy targets (June 2005)

• 112 additional WHO staff deployed to country offices (December 2004).

Despite falling short of the June 2004 target, the number of people on treatment was back on track at the end of 2004. However, the estimated total for the end of June 2005 fell a long way short of the 1.6 million target. The WHO have admitted that:
"Current data and trends indicate that providing ART to 3 million people by the end of 2005 will be unlikely."

So is the 3 by 5 inititative a failure?

The WHO has pointed out that, even if 3 by 5 doesn't succeed within the intended timeframe, this doesn't mean that it should be given up as a failure. Much of 3 by 5's work has been to set up structures by which medication can be delivered to those who most need it. Once the structures are in place, the delivery of medication should begin to accelerate, and the project should ultimately be able to help more than the three million people it was originally intended to.

It should be remembered that treatment for these 970,000 people was not funded by the 3 by 5 initiative itself. The drugs may be paid for by donors such as PEPFAR and the Global Fund; by the affected countries; by employers; or by the recipients themselves.

One of the main players in getting ARV medication to people around the world is US President George Bush. The President's Emergency Plan for AIDS Relief, (PEPFAR) proposed by President Bush in early 2003 was to commit US$15 billion over a five-year period. The money was to be spent on financing the fight against AIDS in low- and middle-income countries. About US$9 billion of this is new money, the remainder made up of money already allocated for overseas aid. About US$1 billion of this money has been pledged to the Global Fund.

Much of the PEPFAR funding is aimed at treating people with free AIDS drugs. PEPFAR backs the use of the expensive brand-name drugs from the big multinational pharmaceutical companies which invented them - and which stand to make considerable profits if they are bought in large quantities for developing countries. It has therefore been accused of directing vast sums of money to these American manufacturers at the cost of the health and lives of many people in African countries. However, since January 2005 the US FDA has approved a number of generic ARV drugs, which may now be bought with PEPFAR funds.

PEPFAR has a goal of having 2 million people on ARVs by 2008. It began spending the money in 2004 and allocated US$2.4 billion for the first year. By the end of March 2005, PEPFAR had helped to provide ARV therapy for 155,000 people in its 15 focus countries (63% of total provision in those countries) and 17,000 elsewhere.3 By the end of June 2005, the total for focus countries had risen to 235,000 - already exceeding the target of 200,000 for June 2005.4 Included in PEPFAR statistics are one third of all people assisted by the Global Fund, since the US provides one third of Global Fund money.